Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases

Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines

Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...

Haemophilus influenzae type B conjugate vaccines.

In summary, all of the Hib conjugate vaccines are highly immunogenic and efficacious in children older than 12-15 months of age, and HbOC, PRP-OMPC, and PRP-T are highly immunogenic and demonstrated to be efficacious in infants as young as 2 months old. HbOC, PRP-OMPC, and PRP-T have been licensed in numerous countries for infants and are recommended for infant immunization. However, perhaps th...

Haemophilus influenzae type b polysaccharide vaccines.

immunogenicity and efficacy of different haemophilus influenzae type b vaccines

haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. the disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. despite the availability of new and more powerful antibiotics children with hib meningitis still suffer from high mortality or morbidity. the emergence of multir...

Prevention of Haemophilus influenzae type b disease.

Haemophilus influenzae type b (Hib) is the leading cause of meningitis in children < 5 years of age. The majority of cases of Hib occur in infants < 2 years of age. Until recently the only vaccine available against this disease contained the pure polysaccharide (PRP) of Hib (Hib-PRP vaccine). The Hib-PRP vaccine was demonstrated to be efficacious in infants > 18 months of age but not below that...